New hope for tumor immunotherapy: the macrophage-related “do not eat me” signaling pathway

The “do not eat me” signaling pathway is extremely active in tumor cells, providing a means for these cells to elude macrophage phagocytosis and escape immune surveillance. Representative markers of this pathway, such as CD47 CD24, are highly expressed numerous tumors. interaction SIRPα with reduces the accumulation non-myosin ⅡA on cell membrane. combination CD24 Siglec10 ultimately leads recruitment SHP-1 or SHP-2 reduce signal transduction. Both them weaken ability macrophages engulf cells. Blocking mutual recognition between CD47-SIRPα CD24-Siglec10 using large molecular proteins small drugs represents promising avenue immunotherapy. Doing so can inhibit transduction enhance clearance rates cancer In paper, we summarize characteristics that affect via classical molecule drugs, which target pathways, pathways. We expect it will offer insight into development new centered blocking pathway.